Publications

2018

J. Majerska; M. Feretzaki; G. Glousker; J. Lingner : Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1; Life Science Alliance. 2018-07-17. DOI : 10.26508/lsa.201800121.
W. Ahmed; J. Lingner : Impact of oxidative stress on telomere biology; Differentiation. 2018. DOI : 10.1016/j.diff.2017.12.002.
G. Glousker; J. Lingner : When Telomerase Causes Telomere Loss; Developmental Cell. 2018-02-05. DOI : 10.1016/j.devcel.2018.01.011.
W. Ahmed; J. Lingner : PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase; Genes & Development. 2018-05-17. DOI : 10.1101/gad.313460.118.

2017

A. Vancevska; K. M. Douglass; V. Pfeiffer; S. Manley; J. Lingner : The telomeric DNA damage response occurs in the absence of chromatin decompaction; Genes & Development. 2017. DOI : 10.1101/gad.294082.116.
J. Majerská; S. Redon; J. Lingner : Quantitative telomeric chromatin isolation protocol for human cells; Methods. 2017. DOI : 10.1016/j.ymeth.2016.08.003.
M. Feretzaki; J. Lingner : A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA; Methods. 2017. DOI : 10.1016/j.ymeth.2016.08.004.
G. Lossaint; J. Lingner : TZAP or not to zap telomeres; Science (New York, N.Y.). 2017. DOI : 10.1126/science.aam7015.

2016

E. Aeby; W. Ahmed; S. Redon; V. Simanis; J. Lingner : Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase; Cell Reports. 2016. DOI : 10.1016/j.celrep.2016.11.071.

2015

E. Aeby; J. Lingner : ALT Telomeres Get Together with Nuclear Receptors; Cell. 2015. DOI : 10.1016/j.cell.2015.02.006.
C. M. Azzalin; J. Lingner : Telomere functions grounding on TERRA firma; Trends In Cell Biology. 2015. DOI : 10.1016/j.tcb.2014.08.007.

2014

A. Porro; S. Feuerhahn; J. Delafontaine; H. Riethman; J. Rougemont et al. : Functional characterization of the TERRA transcriptome at damaged telomeres; Nature Communications. 2014. DOI : 10.1038/ncomms6379.
I. Zemp; J. Lingner : The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7; Journal of Biological Chemistry. 2014. DOI : 10.1074/jbc.M114.596056.
A. Porro; S. Feuerhahn; J. Lingner : TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres; Cell reports. 2014. DOI : 10.1016/j.celrep.2014.01.022.

2013

L. Grolimund; E. Aeby; R. Hamelin; F. Armand; D. Chiappe et al. : A quantitative telomeric chromatin isolation protocol identifies different telomeric states; Nature Communications. 2013. DOI : 10.1038/ncomms3848.
L.-Y. Chen; J. Majerska; J. Lingner : Molecular basis of telomere syndrome caused by CTC1 mutations; Genes & Development. 2013. DOI : 10.1101/gad.222893.113.
V. *Pfeiffer; J. *Crittin; L. Grolimund; J. Lingner : The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening; Embo Journal. 2013. DOI : 10.1038/emboj.2013.217.
L.-Y. Chen; J. Lingner : CST for the grand finale of telomere replication; Nucleus-Austin. 2013. DOI : 10.4161/nucl.25701.
S. Redon; I. Zemp; J. Lingner : A three-state model for the regulation of telomerase by TERRA and hnRNPA1; Nucleic acids research. 2013. DOI : 10.1093/nar/gkt695.
V. Pfeiffer; J. Lingner : Replication of Telomeres and the Regulation of Telomerase; Cold Spring Harbor Perspectives in Biology. 2013. DOI : 10.1101/cshperspect.a010405.
A. **Sauerwald; S. **Sandin; G. Cristofari; S. H. W. Scheres; J. *Lingner et al. : Structure of active dimeric human telomerase; Nature Structural & Molecular Biology. 2013. DOI : 10.1038/nsmb.2530.
M. Makhlouf Brahmi; C. Portmann; D. D'Ambrosio; T. M. Woods; D. Banfi et al. : Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols from; Chemistry - A European Journal. 2013. DOI : 10.1002/chem.201203296.
A. Gupta; S. Sharma; P. Reichenbach; L. Marjavaara; A. K. Nilsson et al. : Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools; Genetics. 2013. DOI : 10.1534/genetics.112.149120.

2012

L.-Y. Chen; S. Redon; J. Lingner : The human CST complex is a terminator of telomerase activity; Nature. 2012. DOI : 10.1038/nature11269.
L.-Y. Chen; J. Lingner : AUF1/HnRNP D RNA Binding Protein Functions in Telomere Maintenance; Molecular Cell. 2012. DOI : 10.1016/j.molcel.2012.06.031.
V. Pfeiffer; J. Lingner : TERRA Promotes Telomere Shortening through Exonuclease 1-Mediated Resection of Chromosome Ends; Plos Genetics. 2012. DOI : 10.1371/journal.pgen.1002747.
D. D'Ambrosio; P. Reichenbach; E. Micheli; A. Alvino; M. Franceschin et al. : Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase; Biochimie. 2012. DOI : 10.1016/j.biochi.2011.12.004.

2011

J. Lingner : Roles of telomeres and telomerase in cancer; Swiss Cancer Bulletin . 2011.
N. Iglesias; S. Redon; V. Pfeiffer; M. Dees; J. Lingner et al. : Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast; EMBO reports. 2011. DOI : 10.1038/embor.2011.73.
H. C. Ferreira; B. Luke; H. Schober; V. Kalck; J. Lingner et al. : The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast; Nature Cell Biology. 2011. DOI : 10.1038/ncb2263.

2010

E. Abreu; E. Aritonovska; P. Reichenbach; G. Cristofari; B. Culp et al. : TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo; Molecular and cellular biology. 2010. DOI : 10.1128/MCB.00240-10.
S. Feuerhahn; N. Iglesias; A. Panza; A. Porro; J. Lingner : TERRA biogenesis, turnover and implications for function; FEBS letters. 2010. DOI : 10.1016/j.febslet.2010.07.032.
S. Redon; P. Reichenbach; J. Lingner : The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase; Nucleic acids research. 2010. DOI : 10.1093/nar/gkq296.
A. Porro; S. Feuerhahn; P. Reichenbach; J. Lingner : Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways; Molecular and cellular biology. 2010. DOI : 10.1128/MCB.00460-10.

2009

M. Chang; B. Luke; C. Kraft; Z. Li; M. Peter et al. : Telomerase is essential to alleviate pif1-induced replication stress at telomeres; Genetics. 2009. DOI : 10.1534/genetics.109.107631.
B. Luke; J. Lingner : TERRA: telomeric repeat-containing RNA; EMBO J.. 2009. DOI : 10.1038/emboj.2009.166.
N. Iglesias; J. Lingner : Related mechanisms for end processing at telomeres and DNA double-strand breaks; Mol. Cell. 2009. DOI : 10.1016/j.molcel.2009.07.007.

2008

B. Luke; A. Panza; S. Redon; N. Iglesias; Z. Li et al. : The Rat1p 5’ to 3’ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae; Mol. Cell. 2008. DOI : 10.1016/j.molcel.2008.10.019.
M. Chang; J. Lingner : Cell signaling: Tel2 finally tells one story; Science. 2008. DOI : 10.1126/science.1155132.
C. M. Azzalin; J. Lingner : Telomeres: the silence is broken; Cell Cycle. 2008.

2007

S. Redon; P. Reichenbach.; J. Lingner : Protein-RNA and protein-protein interactions mediate association of human EST1A/SMG6 with telomerase; Nucleic Acids Res.. 2007. DOI : 10.1093/nar/gkm724.
B. Luke; C. M. Azzalin; N. Hug; A. Deplazes; M. Peter et al. : Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense mediated mRNA decay; Nucleic Acids Res.. 2007. DOI : 10.1093/nar/gkm912.
A. De Cian; G. Cristofari; P. Reichenbach; E. De Lemos; D. Monchaud et al. : Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action; Proc Natl Acad Sci U S A. 2007. DOI : 10.1073/pnas.0707365104.
C. M. Azzalin; P. Reichenbach; L. Khoriauli; E. Giulotto; J. Lingner : Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends; Science. 2007. DOI : 10.1126/science.1147182.
M. Arneric; J. Lingner : Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast; EMBO Rep. 2007. DOI : 10.1038/sj.embor.7401082.
C. M. Azzalin; J. Lingner : Molecular biology: damage control; Nature. 2007. DOI : 10.1038/4481001a.
M. Chang; M. Arneric; J. Lingner : Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae; Genes Dev. 2007.
G. Cristofari; E. Adolf; P. Reichenbach; K. Sikora; R. M. Terns et al. : Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation; Mol Cell. 2007. DOI : 10.1016/j.molcel.2007.07.020.
G. Cristofari; P. Reichenbach; P. O. Regamey; D. Banfi; M. Chambon et al. : Low- to high-throughput analysis of telomerase modulators with Telospot; Nat Methods. 2007. DOI : 10.1038/nmeth1099.
G. Cristofari; K. Sikora; J. Lingner : Telomerase unplugged; ACS Chem Biol. 2007. DOI : 10.1021/cb700037c.

2006

C. M. Azzalin; J. Lingner : The human RNA surveillance factor UPF1 is required for S phase progression and genome stability; Curr Biol. 2006. DOI : 10.1016/j.cub.2006.01.018.
C. M. Azzalin; J. Lingner : The double life of UPF1 in RNA and DNA stability pathways; Cell Cycle. 2006.
G. Cristofari; J. Lingner : Telomere length homeostasis requires that telomerase levels are limiting; Embo J. 2006. DOI : 10.1038/sj.emboj.7600952.
A. Eugster; C. Lanzuolo; M. Bonneton; P. Luciano; A. Pollice et al. : The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation; Nat Struct Mol Biol. 2006. DOI : 10.1038/nsmb1126.
N. Hug; J. Lingner : Telomere length homeostasis; Chromosoma. 2006. DOI : 10.1007/s00412-006-0067-3.

2005

K. Förstemann; J. Lingner : Telomerase limits the extent of base pairing between template RNA and telomeric DNA; EMBO Rep. 2005.
C. Kelleher; I. Kurth; J. Lingner : Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro; Mol Cell Biol. 2005. DOI : 10.1128/MCB.25.2.808-818.2005.

2004

C. M. Azzalin; J. Lingner : Cell biology. Telomere wedding ends in divorce; Science. 2004. DOI : 10.1126/science.1096809.
M. T. Teixeira; M. Arneric; P. Sperisen; J. Lingner : Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States; Cell. 2004. DOI : 10.1016/S0092-8674(04)00334-4.

2003

G. Cristofari; J. Lingner : Fingering the ends. How to make new telomeres; Cell. 2003. DOI : 10.1016/S0092-8674(03)00397-0.
K. Förstemann; A. J. Zaug; T. R. Cech; J. Lingner : Yeast telomerase is specialized for C/A-rich RNA templates; Nucleic Acids Res. 2003. DOI : 10.1093/nar/gkg261.
P. Reichenbach; M. Hoss; C. M. Azzalin; M. Nabholz; P. Bucher et al. : A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed; Curr Biol. 2003. DOI : 10.1016/S0960-9822(03)00173-8.
H. Szutorisz; J. Lingner; A. P. Cuthbert; D. A. Trott; R. F. Newbold et al. : A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin; Cancer Res. 2003.

2002

A. L. Ducrest; M. Amacker; J. Lingner; M. Nabholz : Detection of promoter activity by flow cytometric analysis of GFP reporter expression; Nucleic Acids Res. 2002. DOI : 10.1093/nar/gnf064.
A. L. Ducrest; H. Szutorisz; J. Lingner; M. Nabholz : Regulation of the human telomerase reverse transcriptase gene; Oncogene. 2002. DOI : 10.1038/sj.onc.1205081.
C. Kelleher; M. T. Teixeira; K. Förstemann; J. Lingner : Telomerase: biochemical considerations for enzyme and substrate; Trends Biochem Sci. 2002. DOI : 10.1016/S0968-0004(02)02206-5.
E. Pascolo; C. Wenz; J. Lingner; N. Hauel; H. Priepke et al. : Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate; J Biol Chem. 2002. DOI : 10.1074/jbc.M201266200.
M. T. Teixeira; K. Förstemann; S. M. Gasser; J. Lingner : Intracellular trafficking of yeast telomerase components; EMBO Rep. 2002. DOI : 10.1093/embo-reports/kvf133.

2001

K. Damm; U. Hemmann; P. Garin-Chesa; N. Hauel; I. Kauffmann et al. : A highly selective telomerase inhibitor limiting human cancer cell proliferation; Embo J. 2001. DOI : 10.1093/emboj/20.24.6958.
A. L. Ducrest; M. Amacker; Y. D. Mathieu; A. P. Cuthbert; D. A. Trott et al. : Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity; Cancer Res. 2001.
K. Förstemann; J. Lingner : Molecular basis for telomere repeat divergence in budding yeast; Mol Cell Biol. 2001.
H. Szutorisz; R. Palmqvist; G. Roos; R. Stenling; D. F. Schorderet et al. : Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas; Oncogene. 2001. DOI : 10.1038/sj.onc.1204346.
C. Wenz; B. Enenkel; M. Amacker; C. Kelleher; K. Damm et al. : Human telomerase contains two cooperating telomerase RNA molecules; Embo J. 2001. DOI : 10.1093/emboj/20.13.3526.

2000

S. Aigner; J. Lingner; K. J. Goodrich; C. A. Grosshans; A. Shevchenko et al. : Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting; Embo J. 2000. DOI : 10.1093/emboj/19.22.6230.
K. Förstemann; M. Hoss; J. Lingner : Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres; Nucleic Acids Res. 2000. DOI : 10.1093/nar/28.14.2690.

1999

M. A. Blasco; S. M. Gasser; J. Lingner : Telomeres and telomerase; Genes Dev.. 1999. DOI : 10.1101/gad.13.18.2353.
K. J. Wu; C. Grandori; M. Amacker; N. Simon-Vermot; A. Polack et al. : Direct activation of TERT transcription by c-MYC; Nat Genet. 1999.

1998

J. Lingner : Telomerase : the reverse transcriptase subunit as a key to enzymatic function and regulation during cell immortalization; Swiss Cancer Bulletin. 1998.
J. Lingner; T. R. Cech : Telomerase and chromosome end maintenance; Curr Opin Genet Dev. 1998. DOI : 10.1016/S0959-437X(98)80145-7.

1997

T. R. Cech; J. Lingner : Telomerase and the chromosome end replication problem; Ciba Found Symp. 1997.
T. R. Cech; T. M. Nakamura; J. Lingner : Telomerase is a true reverse transcriptase. A review; Biochemistry (Mosc). 1997.
J. Lingner; T. R. Cech; T. R. Hughes; V. Lundblad : Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity; Proc Natl Acad Sci U S A. 1997. DOI : 10.1073/pnas.94.21.11190.
J. Lingner; T. R. Hughes; A. Shevchenko; M. Mann; V. Lundblad et al. : Reverse transcriptase motifs in the catalytic subunit of telomerase; Science. 1997. DOI : 10.1126/science.276.5312.561.
T. M. Nakamura; G. B. Morin; K. B. Chapman; S. L. Weinrich; W. H. Andrews et al. : Telomerase catalytic subunit homologs from fission yeast and human; Science. 1997. DOI : 10.1126/science.277.5328.955.

1996

J. Lingner; T. R. Cech : Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang; Proc Natl Acad Sci U S A. 1996. DOI : 10.1073/pnas.93.20.10712.
A. J. Zaug; J. Lingner; T. R. Cech : Method for determining RNA 3' ends and application to human telomerase RNA; Nucleic Acids Res. 1996. DOI : 10.1093/nar/24.3.532.

1995

J. Lingner; J. P. Cooper; T. R. Cech : Telomerase and DNA end replication: no longer a lagging strand problem?; Science. 1995.
P. J. Preker; J. Lingner; L. Minvielle-Sebastia; W. Keller : The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Cell. 1995. DOI : 10.1016/0092-8674(95)90391-7.

1994

J. Lingner; L. L. Hendrick; T. R. Cech : Telomerase RNAs of different ciliates have a common secondary structure and a permuted template; Genes Dev. 1994. DOI : 10.1101/gad.8.16.1984.

1993

J. Lingner; W. Keller : 3'-end labeling of RNA with recombinant yeast poly(A) polymerase; Nucleic Acids Res. 1993. DOI : 10.1093/nar/21.12.2917.

1991

J. Lingner; J. Kellermann; W. Keller : Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae; Nature. 1991. DOI : 10.1038/354496a0.
J. Lingner; I. Radtke; E. Wahle; W. Keller : Purification and characterization of poly(A) polymerase from Saccharomyces cerevisiae; J Biol Chem. 1991.

1989

C. Price; J. Lingner; T. A. Bickle; K. Firman; S. W. Glover : Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes; J Mol Biol. 1989. DOI : 10.1016/0022-2836(89)90369-0.